to the gut of newborns appears to decrease
of developing colic, according to a study published Monday, the latest showing probiotics' beneficial
effect on the condition.
is thought to be the first to examine whether giving 'good' micro-organisms to infants could prevent the development of what is known as functional gastrointestinal disease, which includes colic, regurgitation and constipation.
周一发布的研究显示，来自意大利巴里阿尔多•莫罗大学(Aldo Moro University)的科学家让589名健康婴儿的父母在他们孩子出生后的头三个月每日给孩子服用五滴包含罗伊氏乳杆菌的滴剂或者安慰剂。罗伊氏乳杆菌对健康的影响已经经过充分研究。
Colic, characterized by lengthy crying, is believed to be related
problems and sometimes likened to an infant
form of irritable
bowel syndrome. The condition has long been a source of anxiety
for new parents, who are often driven
to try all types of home remedies to soothe
their babies in the absence
of any medicines indicated for the treatment
of colic. A recent study found that as many as 20% of infants suffer from colic in their first three months of life.
In the study published Monday, scientists from Aldo Moro University in Bari, Italy, had parents administer
five drops of a solution
containing Lactobacillus reuteri, a bacterium well-studied for its health effects, or a placebo to 589 healthy
infants daily for the first 90 days of life.
在头三个月，服用了益生菌的婴儿的哭闹时间大大减少，每天难以安抚的哭闹时间平均从71分钟降至38分钟，吐奶次数减少，同时肠蠕动增加，这意味着便秘情况减少。这份研究报告周一刊登在美国医学协会(American Medical Association)的期刊《JAMA Pediatrics》上。
At three months, the babies who received the probiotic exhibited significantly reduced crying time--an average of 38 minutes versus 71 minutes of inconsolable crying per day--fewer spit-ups and more bowel movements, which signaled less constipation, according to Flavia Indrio, a pediatrics professor at the university and the lead author on the study. The research
was published Monday in JAMA Pediatrics, a journal
of the American Medical Association.
Previous studies, including one of Dr. Indrio's, have found that Lactobacillus reuteri appears to help with colic, but haven't looked at ways to prevent it. Scientists and industry also are studying whether probiotics can be helpful in treating a number of conditions, including allergies, cholesterol and the common cold.
in babies' gastrointestinal problems may be important not just for infants' well-being
but also health at older ages. Research has found that colic symptoms and development of other gastrointestinal diseases later in life appear to be linked. There have been no reports of adverse
events so far in human Lactobacillus reuteri studies.
休斯顿贝勒医学院(Baylor College of Medicine)儿科系教授Bruno Chumpitazi称，最新的研究做的非常好，结果令人鼓舞。该研究被认为是迄今为止人类对益生菌缓解肠绞痛进行的最大规模的研究，Chumpitazi没有参与该研究但为研究报告撰写了一篇评论。他称，益生菌对健康的长期作用仍是未知的，还需要进行研究。
The latest work, considered the largest human study of probiotics on colic to date, is 'very well done' and the results are encouraging, according to Bruno Chumpitazi, a professor in the department of pediatrics at the Baylor College of Medicine in Houston, who wasn't involved in the research
but wrote an editorial
to accompany the study. The long-term effects of the bacterium on health are still unknown and need to be studied, he said.
Colonies of Lactobacillus reuteri appear to reduce intestinal inflammation, improve movement
in the intestines and lessen
sensitivity to pain, according to Dr. Indrio, but more research
is needed to understand exactly what the bacterium does in the body, she and other experts say. Dr. Indrio plans to follow the cohort of infants to study their rates of irritable
bowel syndrome and gastrointestinal disorders at older ages.
By intervening early or even preventing the start of gastrointestinal distress
in infancy, the path of disease development may be changed. 'Maybe the intestine
and the brain have a different script
to follow,' said Dr. Indrio.